Nabil A.S. Eid

Gross Anatomy, Apoptosis, Autophagy

 Autophagy is a lysosomal degradation of cellular components within autophagic vacuoles following multiple forms of cellular stress, including starvation, hypoxia, oxidative stress, damaged DNA, protein aggregates, damaged mitochondria and lipogenic challenge. Whether it is bulk or selective autophagy (mitophagy, lipophagy), recent studies conclude that ethanol-induced autophagy may regulate steatosis, apoptosis, fibrosis and even cancer in various organs.

Fig.1 Increased autophagic vacuoles formation in steatotic hepatocytes of ethanol-treated rats (ETRs). Short arrows, autophagosomes, long arrows autolysosomes. BC bile canaliculi. Eid N, Ito Y, Maemura k and Otsuki Y, 2013, J Mol Histol.

 My research areas include: The morphological evidence and possible roles of autophagy in ethanol-induced damage of various organs in addition to the cross talk between autophagy and apoptosis. The possible roles of autophagy in various diseases are also investigated. Surgical anatomy, anatomical variations , medical history and education.